Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50448700'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50448700 (CHEMBL3127862) Show SMILES OCCOc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:22.25,wD:15.16,TLB:14:15:19:21.22.24,25:22:15.16.17:19,THB:25:16:19:21.22.24,24:22:15:17.18.19,24:18:15:21.25.22,23:22:15:17.18.19,23:22:15.16.17:19,(2.26,-7.56,;3.42,-6.55,;4.87,-7.05,;6.03,-6.04,;7.49,-6.54,;7.94,-8.01,;9.48,-8.03,;10.37,-9.28,;10.51,-10.82,;11.77,-9.93,;9.98,-6.57,;8.75,-5.65,;11.31,-5.8,;11.31,-4.26,;12.65,-6.56,;13.98,-5.79,;15.48,-5.4,;15.5,-3.81,;16.57,-2.6,;15.21,-3.05,;15.19,-4.54,;16.51,-5.05,;17.92,-4.73,;19.46,-4.69,;17.96,-3.2,;16.88,-5.99,)| Show InChI InChI=1S/C19H26N2O4S/c22-3-4-25-18-21-15(11-1-2-11)16(26-18)17(23)20-14-12-5-10-6-13(14)9-19(24,7-10)8-12/h10-14,22,24H,1-9H2,(H,20,23)/t10?,12?,13?,14-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of N-terminal 6-His-tagged full-length human 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF...				J Med Chem 57: 970-86 (2014) Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50448700 (CHEMBL3127862) Show SMILES OCCOc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:22.25,wD:15.16,TLB:14:15:19:21.22.24,25:22:15.16.17:19,THB:25:16:19:21.22.24,24:22:15:17.18.19,24:18:15:21.25.22,23:22:15:17.18.19,23:22:15.16.17:19,(2.26,-7.56,;3.42,-6.55,;4.87,-7.05,;6.03,-6.04,;7.49,-6.54,;7.94,-8.01,;9.48,-8.03,;10.37,-9.28,;10.51,-10.82,;11.77,-9.93,;9.98,-6.57,;8.75,-5.65,;11.31,-5.8,;11.31,-4.26,;12.65,-6.56,;13.98,-5.79,;15.48,-5.4,;15.5,-3.81,;16.57,-2.6,;15.21,-3.05,;15.19,-4.54,;16.51,-5.05,;17.92,-4.73,;19.46,-4.69,;17.96,-3.2,;16.88,-5.99,)| Show InChI InChI=1S/C19H26N2O4S/c22-3-4-25-18-21-15(11-1-2-11)16(26-18)17(23)20-14-12-5-10-6-13(14)9-19(24,7-10)8-12/h10-14,22,24H,1-9H2,(H,20,23)/t10?,12?,13?,14-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of N-terminal 6-His-tagged full-length mouse 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF...				J Med Chem 57: 970-86 (2014) Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149
					More data for this Ligand-Target Pair