Found 3 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50448723' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50448723
(CHEMBL3127891)Show SMILES Cc1nc(OCC(F)(F)F)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:22.24,wD:15.15,TLB:14:15:19:21.22.24,25:22:15.16.17:19,THB:25:16:19:21.22.24,24:22:15:17.18.19,24:18:15:21.25.22,23:22:15:17.18.19,23:22:15.16.17:19,(36.2,-29.53,;37.66,-30.03,;38.11,-31.5,;39.65,-31.53,;40.53,-32.79,;42.07,-32.65,;42.95,-33.91,;44.49,-33.77,;42.31,-35.31,;44.04,-35,;40.15,-30.07,;38.92,-29.15,;41.48,-29.29,;41.47,-27.75,;42.82,-30.06,;44.15,-29.28,;45.65,-28.9,;45.67,-27.31,;46.73,-26.09,;45.38,-26.54,;45.36,-28.03,;46.68,-28.55,;48.09,-28.22,;49.62,-28.19,;48.12,-26.69,;47.05,-29.48,)| Show InChI InChI=1S/C17H21F3N2O3S/c1-8-21-15(25-7-17(18,19)20)13(26-8)14(23)22-12-10-2-9-3-11(12)6-16(24,4-9)5-10/h9-12,24H,2-7H2,1H3,(H,22,23)/t9?,10?,11?,12-,16- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 11beta-HSD1 using cortisone/[3H]-cortisone as substrate after 5 hrs by reverse-phase HPLC analysis |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50448723
(CHEMBL3127891)Show SMILES Cc1nc(OCC(F)(F)F)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:22.24,wD:15.15,TLB:14:15:19:21.22.24,25:22:15.16.17:19,THB:25:16:19:21.22.24,24:22:15:17.18.19,24:18:15:21.25.22,23:22:15:17.18.19,23:22:15.16.17:19,(36.2,-29.53,;37.66,-30.03,;38.11,-31.5,;39.65,-31.53,;40.53,-32.79,;42.07,-32.65,;42.95,-33.91,;44.49,-33.77,;42.31,-35.31,;44.04,-35,;40.15,-30.07,;38.92,-29.15,;41.48,-29.29,;41.47,-27.75,;42.82,-30.06,;44.15,-29.28,;45.65,-28.9,;45.67,-27.31,;46.73,-26.09,;45.38,-26.54,;45.36,-28.03,;46.68,-28.55,;48.09,-28.22,;49.62,-28.19,;48.12,-26.69,;47.05,-29.48,)| Show InChI InChI=1S/C17H21F3N2O3S/c1-8-21-15(25-7-17(18,19)20)13(26-8)14(23)22-12-10-2-9-3-11(12)6-16(24,4-9)5-10/h9-12,24H,2-7H2,1H3,(H,22,23)/t9?,10?,11?,12-,16- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal 6-His-tagged full-length human 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF... |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50448723
(CHEMBL3127891)Show SMILES Cc1nc(OCC(F)(F)F)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:22.24,wD:15.15,TLB:14:15:19:21.22.24,25:22:15.16.17:19,THB:25:16:19:21.22.24,24:22:15:17.18.19,24:18:15:21.25.22,23:22:15:17.18.19,23:22:15.16.17:19,(36.2,-29.53,;37.66,-30.03,;38.11,-31.5,;39.65,-31.53,;40.53,-32.79,;42.07,-32.65,;42.95,-33.91,;44.49,-33.77,;42.31,-35.31,;44.04,-35,;40.15,-30.07,;38.92,-29.15,;41.48,-29.29,;41.47,-27.75,;42.82,-30.06,;44.15,-29.28,;45.65,-28.9,;45.67,-27.31,;46.73,-26.09,;45.38,-26.54,;45.36,-28.03,;46.68,-28.55,;48.09,-28.22,;49.62,-28.19,;48.12,-26.69,;47.05,-29.48,)| Show InChI InChI=1S/C17H21F3N2O3S/c1-8-21-15(25-7-17(18,19)20)13(26-8)14(23)22-12-10-2-9-3-11(12)6-16(24,4-9)5-10/h9-12,24H,2-7H2,1H3,(H,22,23)/t9?,10?,11?,12-,16- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 637 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal 6-His-tagged full-length mouse 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF... |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |