BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 2A' and Ligand = 'BDBM50133231'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex				J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1
Alcon Research, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]DOI from cloned human 5HT2A receptor expressed in CHO cells				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
Alcon Research, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]LSD from human recombinant 5-HT2A receptor expressed in HEK cells by radioligand completion assay relative to control				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00726 BindingDB Entry DOI: 10.7270/Q2JS9VBR
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
Alcon Research, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex				J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1
Alcon Research, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Alcon Research, Ltd Curated by ChEMBL					Assay Description Displacement of [125I]DOI from 5HT2A receptor in rat cerebral cortex				Bioorg Med Chem Lett 17: 2998-3002 (2007) Article DOI: 10.1016/j.bmcl.2007.03.073 BindingDB Entry DOI: 10.7270/Q2KS6R7B
Alcon Research, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	17.8	n/a	n/a	n/a	n/a
Alcon Research, Ltd Curated by ChEMBL					Assay Description Agonist activity at 5HT2A receptor in rat A7r5 cells assessed as intracellular calcium mobilization relative to 5HT				Bioorg Med Chem Lett 17: 2998-3002 (2007) Article DOI: 10.1016/j.bmcl.2007.03.073 BindingDB Entry DOI: 10.7270/Q2KS6R7B
Alcon Research, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cells				J Med Chem 49: 318-28 (2006) Article DOI: 10.1021/jm050663x BindingDB Entry DOI: 10.7270/Q23B5ZQW
Alcon Research, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50133231 ((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine \|...) Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	27.7	n/a	n/a	n/a	n/a
Alcon Research, Ltd. Curated by ChEMBL					Assay Description In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cells				J Med Chem 46: 4188-95 (2003) Article DOI: 10.1021/jm030205t BindingDB Entry DOI: 10.7270/Q2Z320C1
Alcon Research, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair