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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '5-lipoxygenase/FLAP' and Ligand = 'BDBM50385353'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM50385353
PNG
(CHEMBL2036178)
Show SMILES CC(C)Cc1ccc(cc1)C(C)c1nc2ccccc2n1Cc1ccccc1C#N
Show InChI InChI=1S/C27H27N3/c1-19(2)16-21-12-14-22(15-13-21)20(3)27-29-25-10-6-7-11-26(25)30(27)18-24-9-5-4-8-23(24)17-28/h4-15,19-20H,16,18H2,1-3H3
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Gazi University

Curated by ChEMBL


Assay Description
Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins


Bioorg Med Chem 20: 3728-41 (2012)


Article DOI: 10.1016/j.bmc.2012.04.048
BindingDB Entry DOI: 10.7270/Q26H4JFM
More data for this
Ligand-Target Pair