BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = '72 kDa type IV collagenase' and Ligand = 'BDBM50264809'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50264809 (2-((4-phenoxyphenylsulfonyl)methyl)thiirane \| CHEM...) Show SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	13.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of human MMP2 using fluorogenic substrate by Dixon plot analysis				ACS Med Chem Lett 3: 490-495 (2012) Article DOI: 10.1021/ml300050b BindingDB Entry DOI: 10.7270/Q2T43V4Q
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50264809 (2-((4-phenoxyphenylsulfonyl)methyl)thiirane \| CHEM...) Show SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of MMP2 by substrate hydrolysis based fluorescence spectrophotometry				ACS Med Chem Lett 2: 177-181 (2011) Article DOI: 10.1021/ml100254e BindingDB Entry DOI: 10.7270/Q2N29X6G
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50264809 (2-((4-phenoxyphenylsulfonyl)methyl)thiirane \| CHEM...) Show SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human MMP2 expressed in human HeLaS3 cells using MOCAcPLGLA2pr(Dnp)-AR-NH2 as substrate incubated for 15 to 30 mins by fluo...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00352 BindingDB Entry DOI: 10.7270/Q2BV7M7K
TBA					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50264809 (2-((4-phenoxyphenylsulfonyl)methyl)thiirane \| CHEM...) Show SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem 16: 8781-94 (2008) Article DOI: 10.1016/j.bmc.2008.08.058 BindingDB Entry DOI: 10.7270/Q2JD4WM2
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50264809 (2-((4-phenoxyphenylsulfonyl)methyl)thiirane \| CHEM...) Show SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01855 BindingDB Entry DOI: 10.7270/Q2GB281X
TBA					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50264809 (2-((4-phenoxyphenylsulfonyl)methyl)thiirane \| CHEM...) Show SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Notre Dame Curated by ChEMBL					Assay Description Inhibition of recombinant human MMP2				J Med Chem 61: 8825-8837 (2018) Article DOI: 10.1021/acs.jmedchem.8b01005 BindingDB Entry DOI: 10.7270/Q2BZ68PX
University of Notre Dame Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50264809 (2-((4-phenoxyphenylsulfonyl)methyl)thiirane \| CHEM...) Show SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Notre Dame					Assay Description Inhibition assay using matrix metalloproteinase (MMP-2).				Chem Biol Drug Des 74: 527-34 (2009) Checked by Author Article DOI: 10.1111/j.1747-0285.2009.00881.x BindingDB Entry DOI: 10.7270/Q20P0XJV
University of Notre Dame					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50264809 (2-((4-phenoxyphenylsulfonyl)methyl)thiirane \| CHEM...) Show SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Notre Dame					Assay Description Inhibition assay using matrix metalloproteinase (MMP-2).				Chem Biol Drug Des 74: 527-34 (2009) Checked by Author Article DOI: 10.1111/j.1747-0285.2009.00881.x BindingDB Entry DOI: 10.7270/Q20P0XJV
University of Notre Dame					More data for this Ligand-Target Pair