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Found 1 hit Enz. Inhib. hit(s) with Target = 'ALK tyrosine kinase receptor' and Ligand = 'BDBM50344659'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50344659
PNG
(6,6-dimethyl-8-morpholino-11-oxo-6,11-dihydro-5H-b...)
Show SMILES CC1(C)c2[nH]c3cc(ccc3c2C(=O)c2ccc(cc12)N1CCOCC1)C#N
Show InChI InChI=1S/C23H21N3O2/c1-23(2)18-12-15(26-7-9-28-10-8-26)4-6-16(18)21(27)20-17-5-3-14(13-24)11-19(17)25-22(20)23/h3-6,11-12,25H,7-10H2,1-2H3
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KEGG

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PC cid
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Similars
Article
PubMed
n/an/a 18.5n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assay

Bioorg Med Chem Lett 21: 3788-93 (2011)

Checked by Author
Article DOI: 10.1016/j.bmcl.2011.04.020
BindingDB Entry DOI: 10.7270/Q2Q81DF2
More data for this
Ligand-Target Pair