Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50344664 (6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assay | Bioorg Med Chem Lett 21: 3788-93 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2011.04.020 BindingDB Entry DOI: 10.7270/Q2Q81DF2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50344664 (6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University Curated by ChEMBL | Assay Description Inhibition of ALK (unknown origin) | J Med Chem 62: 10927-10954 (2019) Article DOI: 10.1021/acs.jmedchem.9b00446 BindingDB Entry DOI: 10.7270/Q2S185WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50344664 (6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ALK activity by TR-FRET assay | J Med Chem 54: 6286-94 (2011) Article DOI: 10.1021/jm200652u BindingDB Entry DOI: 10.7270/Q2P55NWZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50344664 (6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.53 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Seiyaku Kabushiki Kaisha US Patent | Assay Description ALK-inhibiting activity was measured by following an activity of inhibiting phosphorylation by biotinylated peptide (EGPWLEEEEEAYGWMDF). For the dete... | US Patent US9126931 (2015) BindingDB Entry DOI: 10.7270/Q22J69N8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50344664 (6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of INSR assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assay | Bioorg Med Chem Lett 21: 3788-93 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2011.04.020 BindingDB Entry DOI: 10.7270/Q2Q81DF2 | |||||||||||
More data for this Ligand-Target Pair |