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Found 1 hit Enz. Inhib. hit(s) with Target = 'ATP-sensitive inward rectifier potassium channel 1' and Ligand = 'BDBM50442605'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM50442605
PNG
(CHEMBL2441431)
Show SMILES [O-][N+](=O)c1ccc(CCN2CCN(CC2)C(=O)Cc2ccc3C(=O)OCc3c2)cc1
Show InChI InChI=1S/C22H23N3O5/c26-21(14-17-3-6-20-18(13-17)15-30-22(20)27)24-11-9-23(10-12-24)8-7-16-1-4-19(5-2-16)25(28)29/h1-6,13H,7-12,14-15H2
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n/an/a 540n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysis

Bioorg Med Chem Lett 23: 5829-32 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.104
BindingDB Entry DOI: 10.7270/Q28K7BHG
More data for this
Ligand-Target Pair