BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Androgen receptor' and Ligand = 'BDBM25428'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Androgen receptor (Rattus norvegicus (Rat))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Michigan Medical School Curated by ChEMBL					Assay Description Inhibition of rat prostate cytosolic androgen receptor				Bioorg Med Chem Lett 14: 5285-8 (2004) Article DOI: 10.1016/j.bmcl.2004.08.031 BindingDB Entry DOI: 10.7270/Q29K4BZG
					More data for this Ligand-Target Pair
Androgen receptor (Rattus norvegicus (Rat))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CSC-Scientific Computing Ltd. Curated by ChEMBL					Assay Description Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostate				J Med Chem 48: 917-25 (2005) Article DOI: 10.1021/jm0495879 BindingDB Entry DOI: 10.7270/Q2SJ1PBD
CSC-Scientific Computing Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Rattus norvegicus (Rat))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Michigan Medical School Curated by ChEMBL					Assay Description Binding affinity against rat prostate cytosolic Androgen receptor using [3H]mibolerone as radioligand				Bioorg Med Chem Lett 11: 1045-7 (2001) BindingDB Entry DOI: 10.7270/Q2SF2WQ5
					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15.9	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]dihydrotestosterone from human androgen receptor expressed in Sf9 cells				Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	4
Pfizer					Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c...				J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1
Pfizer					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system				Bioorg Med Chem Lett 19: 2176-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.104 BindingDB Entry DOI: 10.7270/Q27P8Z8W
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31.1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor expressed in MDA-MB-453 cells				Bioorg Med Chem Lett 17: 5693-7 (2007) Article DOI: 10.1016/j.bmcl.2007.07.059 BindingDB Entry DOI: 10.7270/Q2GH9HPQ
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen receptor (Homo sapiens (Human))	BDBM25428 (4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response				Bioorg Med Chem Lett 19: 2176-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.104 BindingDB Entry DOI: 10.7270/Q27P8Z8W
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair