Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM161577'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM161577 (US9108983, Example 392) Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n1C)C(=O)N(c1ccccc1)c1ccc(O)cc1 Show InChI InChI=1S/C42H43ClN4O4/c1-29-38(42(50)47(33-11-4-3-5-12-33)34-15-17-36(48)18-16-34)27-40(44(29)2)39-26-32(43)14-19-37(39)41(49)46-28-31-10-7-6-9-30(31)25-35(46)13-8-20-45-21-23-51-24-22-45/h3-7,9-12,14-19,26-27,35,48H,8,13,20-25,28H2,1-2H3/t35-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...				US Patent US9108983 (2015) BindingDB Entry DOI: 10.7270/Q2PC314Z
					More data for this Ligand-Target Pair