Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177808'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177808 (US9120791, Example 26 | US9603854, 26) Show SMILES CN1CCCc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C46H48ClN5O4/c1-48-19-6-9-32-26-36(14-18-42(32)48)52(35-12-15-38(53)16-13-35)46(55)41-28-44(50-20-5-4-10-43(41)50)40-27-34(47)11-17-39(40)45(54)51-29-33-8-3-2-7-31(33)25-37(51)30-49-21-23-56-24-22-49/h2-3,7-8,11-18,26-28,37,53H,4-6,9-10,19-25,29-30H2,1H3/t37-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177808 (US9120791, Example 26 | US9603854, 26) Show SMILES CN1CCCc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C46H48ClN5O4/c1-48-19-6-9-32-26-36(14-18-42(32)48)52(35-12-15-38(53)16-13-35)46(55)41-28-44(50-20-5-4-10-43(41)50)40-27-34(47)11-17-39(40)45(54)51-29-33-8-3-2-7-31(33)25-37(51)30-49-21-23-56-24-22-49/h2-3,7-8,11-18,26-28,37,53H,4-6,9-10,19-25,29-30H2,1H3/t37-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair