Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177817'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177817 (US9120791, Example 35 | US9603854, 35) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C47H47N5O6/c1-48-17-15-32-25-35(11-14-41(32)48)52(34-9-12-37(53)13-10-34)47(55)40-26-43(50-16-5-4-8-42(40)50)38-27-44-45(58-23-22-57-44)28-39(38)46(54)51-29-33-7-3-2-6-31(33)24-36(51)30-49-18-20-56-21-19-49/h2-3,6-7,9-15,17,25-28,36,53H,4-5,8,16,18-24,29-30H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177817 (US9120791, Example 35 | US9603854, 35) Show SMILES Cn1ccc2cc(ccc12)N(C(=O)c1cc(-c2cc3OCCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C47H47N5O6/c1-48-17-15-32-25-35(11-14-41(32)48)52(34-9-12-37(53)13-10-34)47(55)40-26-43(50-16-5-4-8-42(40)50)38-27-44-45(58-23-22-57-44)28-39(38)46(54)51-29-33-7-3-2-6-31(33)24-36(51)30-49-18-20-56-21-19-49/h2-3,6-7,9-15,17,25-28,36,53H,4-5,8,16,18-24,29-30H2,1H3/t36-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair