Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177877'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177877 (US9120791, Example 104 | US9603854, 104) Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ncc3c2)c2CCCCn12 Show InChI InChI=1S/C45H46N6O5/c1-47-41-17-12-34(24-32(41)27-46-47)51(33-10-13-36(52)14-11-33)45(54)40-26-43(49-18-6-5-9-42(40)49)39-25-37(55-2)15-16-38(39)44(53)50-28-31-8-4-3-7-30(31)23-35(50)29-48-19-21-56-22-20-48/h3-4,7-8,10-17,24-27,35,52H,5-6,9,18-23,28-29H2,1-2H3/t35-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177877 (US9120791, Example 104 | US9603854, 104) Show SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ncc3c2)c2CCCCn12 Show InChI InChI=1S/C45H46N6O5/c1-47-41-17-12-34(24-32(41)27-46-47)51(33-10-13-36(52)14-11-33)45(54)40-26-43(49-18-6-5-9-42(40)49)39-25-37(55-2)15-16-38(39)44(53)50-28-31-8-4-3-7-30(31)23-35(50)29-48-19-21-56-22-20-48/h3-4,7-8,10-17,24-27,35,52H,5-6,9,18-23,28-29H2,1-2H3/t35-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair