Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177886'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177886 (US9120791, Example 115 | US9603854, 115) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1F Show InChI InChI=1S/C42H40ClFN4O4/c43-30-12-17-34(41(50)47-26-29-8-2-1-7-28(29)23-32(47)27-45-19-21-52-22-20-45)35(24-30)40-25-36(38-10-5-6-18-46(38)40)42(51)48(31-13-15-33(49)16-14-31)39-11-4-3-9-37(39)44/h1-4,7-9,11-17,24-25,32,49H,5-6,10,18-23,26-27H2/t32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177886 (US9120791, Example 115 | US9603854, 115) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccccc1F Show InChI InChI=1S/C42H40ClFN4O4/c43-30-12-17-34(41(50)47-26-29-8-2-1-7-28(29)23-32(47)27-45-19-21-52-22-20-45)35(24-30)40-25-36(38-10-5-6-18-46(38)40)42(51)48(31-13-15-33(49)16-14-31)39-11-4-3-9-37(39)44/h1-4,7-9,11-17,24-25,32,49H,5-6,10,18-23,26-27H2/t32-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair