Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177888'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177888 (US9120791, Example 117 | US9603854, 117) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(F)cc1F Show InChI InChI=1S/C42H39ClF2N4O4/c43-29-8-14-34(41(51)48-25-28-6-2-1-5-27(28)21-32(48)26-46-17-19-53-20-18-46)35(22-29)40-24-36(38-7-3-4-16-47(38)40)42(52)49(31-10-12-33(50)13-11-31)39-15-9-30(44)23-37(39)45/h1-2,5-6,8-15,22-24,32,50H,3-4,7,16-21,25-26H2/t32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177888 (US9120791, Example 117 | US9603854, 117) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(F)cc1F Show InChI InChI=1S/C42H39ClF2N4O4/c43-29-8-14-34(41(51)48-25-28-6-2-1-5-27(28)21-32(48)26-46-17-19-53-20-18-46)35(22-29)40-24-36(38-7-3-4-16-47(38)40)42(52)49(31-10-12-33(50)13-11-31)39-15-9-30(44)23-37(39)45/h1-2,5-6,8-15,22-24,32,50H,3-4,7,16-21,25-26H2/t32-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair