Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177890'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177890 (US9120791, Example 119 | US9603854, 119) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(c1)C#N Show InChI InChI=1S/C43H40ClN5O4/c44-32-11-16-37(42(51)48-27-31-8-2-1-7-30(31)23-35(48)28-46-18-20-53-21-19-46)38(24-32)41-25-39(40-10-3-4-17-47(40)41)43(52)49(33-12-14-36(50)15-13-33)34-9-5-6-29(22-34)26-45/h1-2,5-9,11-16,22,24-25,35,50H,3-4,10,17-21,23,27-28H2/t35-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177890 (US9120791, Example 119 | US9603854, 119) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(c1)C#N Show InChI InChI=1S/C43H40ClN5O4/c44-32-11-16-37(42(51)48-27-31-8-2-1-7-30(31)23-35(48)28-46-18-20-53-21-19-46)38(24-32)41-25-39(40-10-3-4-17-47(40)41)43(52)49(33-12-14-36(50)15-13-33)34-9-5-6-29(22-34)26-45/h1-2,5-9,11-16,22,24-25,35,50H,3-4,10,17-21,23,27-28H2/t35-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair