Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177902'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177902 (US9120791, Example 135 | US9603854, 135) Show SMILES Cn1cc(cn1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C40H41ClN6O4/c1-43-25-32(23-42-43)47(30-10-12-33(48)13-11-30)40(50)36-22-38(45-15-5-4-8-37(36)45)35-21-29(41)9-14-34(35)39(49)46-24-28-7-3-2-6-27(28)20-31(46)26-44-16-18-51-19-17-44/h2-3,6-7,9-14,21-23,25,31,48H,4-5,8,15-20,24,26H2,1H3/t31-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177902 (US9120791, Example 135 | US9603854, 135) Show SMILES Cn1cc(cn1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc(O)cc1 Show InChI InChI=1S/C40H41ClN6O4/c1-43-25-32(23-42-43)47(30-10-12-33(48)13-11-30)40(50)36-22-38(45-15-5-4-8-37(36)45)35-21-29(41)9-14-34(35)39(49)46-24-28-7-3-2-6-27(28)20-31(46)26-44-16-18-51-19-17-44/h2-3,6-7,9-14,21-23,25,31,48H,4-5,8,15-20,24,26H2,1H3/t31-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair