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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM341016'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM341016
PNG
(1-(5-Bromo-2-{[(3S)-3-[(4-methylpiperazin-1-yl)met...)
Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(Br)cc2-n2cc(cc2C)C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)CC1
Show InChI InChI=1S/C43H43BrN6O3/c1-29-22-33(42(52)50(35-9-12-38(51)13-10-35)36-11-15-40-31(24-36)16-17-46(40)3)27-48(29)41-25-34(44)8-14-39(41)43(53)49-26-32-7-5-4-6-30(32)23-37(49)28-47-20-18-45(2)19-21-47/h4-17,22,24-25,27,37,51H,18-21,23,26,28H2,1-3H3/t37-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 2.90n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...

US Patent US9765056 (2017)


BindingDB Entry DOI: 10.7270/Q2T72KJF
More data for this
Ligand-Target Pair