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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM341129'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM341129
PNG
(N-(4-Fluorophenyl)-1-{4-hydroxy-5-methoxy-2-[(3S)-...)
Show SMILES COc1cc(c(cc1O)C(=O)N1Cc2ccccc2C[C@H]1CN1CCN(C)CC1)-n1cc(C(=O)N(c2ccc(O)cc2)c2ccc(F)cc2)c2ccccc12
Show InChI InChI=1S/C44H42FN5O5/c1-46-19-21-47(22-20-46)27-34-23-29-7-3-4-8-30(29)26-48(34)43(53)37-24-41(52)42(55-2)25-40(37)49-28-38(36-9-5-6-10-39(36)49)44(54)50(32-13-11-31(45)12-14-32)33-15-17-35(51)18-16-33/h3-18,24-25,28,34,51-52H,19-23,26-27H2,1-2H3/t34-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...

US Patent US9765056 (2017)


BindingDB Entry DOI: 10.7270/Q2T72KJF
More data for this
Ligand-Target Pair