BindingDB PrimarySearch

Found 18 hits Enz. Inhib. hit(s) with Target = 'Arginase-1' and Ligand = 'BDBM50350311'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	311	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assay				ACS Med Chem Lett 11: 582-588 (2020) Article DOI: 10.1021/acsmedchemlett.0c00058 BindingDB Entry DOI: 10.7270/Q26113VN
Merck & Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	311	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00195 BindingDB Entry DOI: 10.7270/Q2542SD6
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Institutes for Pharmaceutical Discovery Curated by ChEMBL					Assay Description Inhibition of human Arg1				Bioorg Med Chem Lett 23: 2027-30 (2013) Article DOI: 10.1016/j.bmcl.2013.02.024 BindingDB Entry DOI: 10.7270/Q22J6D8K
Institutes for Pharmaceutical Discovery Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Rattus norvegicus)	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Rattus norvegicus)	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of rat Arg1 at pH 7.4				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair
Arginase-1 (Rattus norvegicus)	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics Curated by ChEMBL					Assay Description Inhibition of recombinant human arginase 1 using L-arginine as substrate measured after 60 mins in presence of manganese chloride by o-phthaldialdehy...				ACS Med Chem Lett 11: 433-438 (2020) Article DOI: 10.1021/acsmedchemlett.9b00508 BindingDB Entry DOI: 10.7270/Q24X5C4D
OncoArendi Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institutes for Pharmaceutical Discovery Curated by ChEMBL					Assay Description Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay				Bioorg Med Chem Lett 23: 2027-30 (2013) Article DOI: 10.1016/j.bmcl.2013.02.024 BindingDB Entry DOI: 10.7270/Q22J6D8K
Institutes for Pharmaceutical Discovery Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars		n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institutes for Pharmaceutical Discovery Curated by ChEMBL					Assay Description Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay				Bioorg Med Chem Lett 23: 4837-41 (2013) Article DOI: 10.1016/j.bmcl.2013.06.092 BindingDB Entry DOI: 10.7270/Q2Z89DT6
Institutes for Pharmaceutical Discovery Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
New England Discovery Partners Curated by ChEMBL					Assay Description Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...				J Med Chem 62: 8164-8177 (2019) Article DOI: 10.1021/acs.jmedchem.9b00931 BindingDB Entry DOI: 10.7270/Q2X92FM9
New England Discovery Partners Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.68E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human ARG1 expressed in CHO-K1 cells assessed as reduction in urea level incubated for 24 hrs by colorimetric assay				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Binding affinity to human arginase 1				J Med Chem 54: 5432-43 (2011) Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars		n/a	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars		n/a	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
Drexel University Curated by ChEMBL					Assay Description Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assay				J Med Chem 54: 5432-43 (2011) Article DOI: 10.1021/jm200443b BindingDB Entry DOI: 10.7270/Q2TH8N21
Drexel University Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM50350311 (CHEMBL1812661) Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human Arg1 at pH 8.5				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair