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Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase A' and Ligand = 'BDBM50264549'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))		BDBM50264549
PNG
(CHEMBL491243 | tert-butyl 2-(2-methyl-3-oxoisoindo...)
Show SMILES CN1Cc2cccc(-c3cccn3C(=O)OC(C)(C)C)c2C1=O
Show InChI InChI=1S/C18H20N2O3/c1-18(2,3)23-17(22)20-10-6-9-14(20)13-8-5-7-12-11-19(4)16(21)15(12)13/h5-10H,11H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Aurora A (unknown origin)

Bioorg Med Chem Lett 18: 5130-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.090
BindingDB Entry DOI: 10.7270/Q2RF5TVZ
More data for this
Ligand-Target Pair