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Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase A' and Ligand = 'BDBM50446452'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))		BDBM50446452
PNG
(CHEMBL3109961)
Show SMILES COc1ccccc1Nc1cc2[nH]c(cc2cn1)-c1cnn(C)c1C
Show InChI InChI=1S/C19H19N5O/c1-12-14(11-21-24(12)2)17-8-13-10-20-19(9-16(13)22-17)23-15-6-4-5-7-18(15)25-3/h4-11,22H,1-3H3,(H,20,23)
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MMDB

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Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Aurora A (unknown origin) using 5FAM-LRRASLG-CONH2 as substrate after 60 mins by fluorescence assay

J Med Chem 56: 10045-65 (2013)


Article DOI: 10.1021/jm401395s
BindingDB Entry DOI: 10.7270/Q2JM2C4W
More data for this
Ligand-Target Pair