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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase B' and Ligand = 'BDBM86625'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))		BDBM86625
PNG
(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 3...)
Show SMILES CCN1CCN(Cc2ccc(Nc3ncc4N(C)C(=O)c5ccc(F)cc5N(C)c4n3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C27H29F4N7O/c1-4-37-9-11-38(12-10-37)16-17-5-7-19(14-21(17)27(29,30)31)33-26-32-15-23-24(34-26)35(2)22-13-18(28)6-8-20(22)25(39)36(23)3/h5-8,13-15H,4,9-12,16H2,1-3H3,(H,32,33,34)
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Harvard Medical School



Assay Description
In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.

ACS Chem Biol 7: 185-96 (2012)


Article DOI: 10.1021/cb200305u
BindingDB Entry DOI: 10.7270/Q2PV6HZG
More data for this
Ligand-Target Pair