Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human)) | BDBM283998 (E24 | US10023564, Example 24) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 240 | n/a | n/a | n/a | n/a | 7.0 | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human)) | BDBM283998 (E24 | US10023564, Example 24) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assay | Bioorg Med Chem Lett 28: 1507-1515 (2018) Article DOI: 10.1016/j.bmcl.2018.03.082 BindingDB Entry DOI: 10.7270/Q22Z1868 | |||||||||||
More data for this Ligand-Target Pair |