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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-adrenergic receptor kinase 1' and Ligand = 'BDBM50257454'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-adrenergic receptor kinase 1


(Homo sapiens (Human))		BDBM50257454
PNG
(CHEMBL4085247)
Show SMILES O=C(CNc1cccc(Oc2ccccc2)c1)N\N=C1/CCCc2cnccc12
Show InChI InChI=1S/C23H22N4O2/c28-23(27-26-22-11-4-6-17-15-24-13-12-21(17)22)16-25-18-7-5-10-20(14-18)29-19-8-2-1-3-9-19/h1-3,5,7-10,12-15,25H,4,6,11,16H2,(H,27,28)/b26-22+
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Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Shonan Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.

Curated by ChEMBL


Assay Description
Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...

J Med Chem 60: 6942-6990 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00443
BindingDB Entry DOI: 10.7270/Q280552Z
More data for this
Ligand-Target Pair