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Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-ketoacyl-ACP synthase (KasA)' and Ligand = 'BDBM93049'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-ketoacyl-ACP synthase (KasA)


(Mycobacterium tuberculosis)
BDBM93049
PNG
(TLM analog, 6)
Show SMILES C\C(C=C)=C/[C@@]1(C)SC(=O)C(C(=O)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C12H11F3O3S/c1-4-6(2)5-11(3)8(16)7(10(18)19-11)9(17)12(13,14)15/h4-5,7H,1H2,2-3H3/b6-5+/t7?,11-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.18E+4n/an/an/a8.5n/a



Institute for Chemical Biology & Drug Discovery



Assay Description
Binding of TLM and the TLM analogs to KasA was quantified by monitoring changes in the intrinsic tryptophan fluroescence of the enzyme using 280-nm e...


J Biol Chem 288: 6045-52 (2013)


Article DOI: 10.1074/jbc.M112.414516
More data for this
Ligand-Target Pair