Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM228963'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM228963 (US9556135, 125) Show SMILES C[C@]1(CS(=O)(=O)[C@@]2(C[C@H](F)C2)C(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F |r,wU:6.10,wD:1.0,8.8,c:13,(6,-2.63,;4.67,-1.86,;6,-1.09,;6,.45,;7.34,1.22,;7.34,-.32,;4.67,1.22,;3.58,2.31,;4.67,3.4,;4.67,4.94,;5.76,2.31,;3.33,.45,;2,1.22,;3.33,-1.09,;3.33,-2.63,;2,-1.86,;.67,-2.63,;-.67,-1.86,;-2,-2.63,;-2,-4.17,;-3.33,-1.86,;-4.67,-2.63,;-6,-1.86,;-6,-.32,;-7.34,.45,;-4.67,.45,;-3.33,-.32,;.67,-4.17,;2,-4.94,;3.33,-4.17,;4.67,-4.94,)| Show InChI InChI=1S/C20H19ClF2N4O3S/c1-19(10-31(29,30)20(18(24)27-19)7-12(22)8-20)14-6-13(3-4-15(14)23)26-17(28)16-5-2-11(21)9-25-16/h2-6,9,12H,7-8,10H2,1H3,(H2,24,27)(H,26,28)/t12-,19-,20+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. US Patent					Assay Description Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...				US Patent US9556135 (2017) BindingDB Entry DOI: 10.7270/Q2X0691F
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