BindingDB PrimarySearch

Found 10 hits Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM47353'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	1.75	n/a	n/a	n/a	n/a	n/a	n/a	5.01	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The protocol that was used to determine the recited values isdescribed as follows.BACE1 HTRF FRET AssayReagentsNa+-Acetate pH 5.01% Brij-35GlycerolDi...				US Patent US8940748 (2015) BindingDB Entry DOI: 10.7270/Q2ZC81MM
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	1.75	-50.8	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description A homogeneous time-resolved FRET assay was used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay monit...				US Patent US9029362 (2015) BindingDB Entry DOI: 10.7270/Q2X63KP6
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	4.88	-48.2	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description Inhibitor IC50s at purified human autoBACE-2 were determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEV...				US Patent US9029362 (2015) BindingDB Entry DOI: 10.7270/Q2X63KP6
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	4.88	-48.2	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description A homogeneous time-resolved FRET assay was used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay monit...				US Patent US9029362 (2015) BindingDB Entry DOI: 10.7270/Q2X63KP6
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a	5.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description This assay monitored the increase of 620 nm fluorescence that resulted from BACE1 cleavage of an APPswedish APPswe mutant peptide FRET substrate (QSY...				US Patent US9687494 (2017) BindingDB Entry DOI: 10.7270/Q2CJ8BN7
Merck Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
University of Tehran Curated by ChEMBL					Assay Description Inhibition of BACE1 (unknown origin)				Eur J Med Chem 138: 729-737 (2017) Article DOI: 10.1016/j.ejmech.2017.06.040 BindingDB Entry DOI: 10.7270/Q2NC63S4
University of Tehran Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01858 BindingDB Entry DOI: 10.7270/Q2GH9NQT
TBA					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human BACE1				J Med Chem 61: 4476-4504 (2018) Article DOI: 10.1021/acs.jmedchem.8b00246 BindingDB Entry DOI: 10.7270/Q23J3GJ5
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant human BACE1 preincubated with enzyme for 20 mins followed by addition of Rh-EVNLDAEFK-Quencher as substrate measured after ...				Eur J Med Chem 167: 133-145 (2019) Article DOI: 10.1016/j.ejmech.2019.02.008 BindingDB Entry DOI: 10.7270/Q2B27ZK8
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM47353 (BDBM143220 \| US9029362, 173 \| US9687494, 25) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of BACE-1 (unknown origin) using Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-Dnp-OH as substrate preincubated for 30 mins followed by subs...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113441 BindingDB Entry DOI: 10.7270/Q2XG9VXP
TBA					More data for this Ligand-Target Pair