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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM335431'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-secretase 2


(Homo sapiens (Human))		BDBM335431
PNG
(8-((4-((3R,6S)-5-amino-6- cyclopropyl-3,6-dimethyl...)
Show SMILES C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2nccc3cc(cnc23)C#N)ncc1F |r,c:13|
Show InChI InChI=1S/C23H22FN7O2S/c1-22(12-34(32,33)23(2,15-3-4-15)21(26)31-22)16-8-18(28-11-17(16)24)30-20-19-14(5-6-27-20)7-13(9-25)10-29-19/h5-8,10-11,15H,3-4,12H2,1-2H3,(H2,26,31)(H,27,28,30)/t22-,23-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
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UniChem
US Patent
 1.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC...

US Patent US9732088 (2017)


BindingDB Entry DOI: 10.7270/Q2XD13S2
More data for this
Ligand-Target Pair