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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'C-Raf (Y340D/Y341D)' and Ligand = 'BDBM186831'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-Raf (Y340D/Y341D)


(Homo sapiens (Human))
BDBM186831
PNG
(US9670203, Compound 1.23)
Show SMILES Fc1cc(F)cc(NC(=O)N[C@@H]2[C@H]3Oc4ccc(Oc5ccnc6NC(=O)CCc56)cc4[C@@H]23)c1 |r|
Show InChI InChI=1/C24H18F2N4O4/c25-11-7-12(26)9-13(8-11)28-24(32)30-21-20-16-10-14(1-3-17(16)34-22(20)21)33-18-5-6-27-23-15(18)2-4-19(31)29-23/h1,3,5-10,20-22H,2,4H2,(H,27,29,31)(H2,28,30,32)/t20-,21-,22-/s2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 300n/an/an/an/an/a25



BeiGene, Ltd.

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9670203 (2017)


Article DOI: 10.1021/jm960802y
More data for this
Ligand-Target Pair