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Found 1 hit Enz. Inhib. hit(s) with Target = 'CREB-binding protein/Histone acetyltransferase p300' and Ligand = 'BDBM50200457'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
CREB-binding protein/Histone acetyltransferase p300


(Homo sapiens (Human))		BDBM50200457
PNG
(CHEMBL3943463 | US9763922, Example 220)
Show SMILES CN(C)C(=O)c1cccc(Nc2nn(CC3CC3)c3CCN(Cc23)C(C)=O)c1
Show InChI InChI=1S/C21H27N5O2/c1-14(27)25-10-9-19-18(13-25)20(23-26(19)12-15-7-8-15)22-17-6-4-5-16(11-17)21(28)24(2)3/h4-6,11,15H,7-10,12-13H2,1-3H3,(H,22,23)
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Similars
Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay

J Med Chem 59: 10549-10563 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF
More data for this
Ligand-Target Pair