Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CREB-binding protein (Homo sapiens (Human)) | BDBM50178208 (CHEMBL3814706 | US10206931, Example 133) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | >1.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent | Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ... | US Patent US10206931 (2019) BindingDB Entry DOI: 10.7270/Q2GM89FR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CREB-binding protein (Homo sapiens (Human)) | BDBM50178208 (CHEMBL3814706 | US10206931, Example 133) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Constellation Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay | ACS Med Chem Lett 7: 531-6 (2016) Article DOI: 10.1021/acsmedchemlett.6b00075 BindingDB Entry DOI: 10.7270/Q20G3N3S | |||||||||||
More data for this Ligand-Target Pair |