new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Calcitonin gene-related peptide type 1 receptor' and Ligand = 'BDBM50192553'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))
BDBM50192553
PNG
((R)-4-(4-(3-methoxyphenyl)-2-oxo-2,3-dihydroimidaz...)
Show SMILES COc1cccc(c1)-c1cn(C2CCN(CC2)C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)c(=O)[nH]1 |t:23|
Show InChI InChI=1S/C33H31F3N6O4/c1-46-24-11-7-10-22(18-24)26-19-41(32(45)37-26)23-14-16-40(17-15-23)31(44)39-29-30(43)42(20-33(34,35)36)27-13-6-5-12-25(27)28(38-29)21-8-3-2-4-9-21/h2-13,18-19,23,29H,14-17,20H2,1H3,(H,37,45)(H,39,44)/t29-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]CGRP from human recombinant CGRP receptor


Bioorg Med Chem Lett 16: 5052-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.044
BindingDB Entry DOI: 10.7270/Q29S1QNX
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))
BDBM50192553
PNG
((R)-4-(4-(3-methoxyphenyl)-2-oxo-2,3-dihydroimidaz...)
Show SMILES COc1cccc(c1)-c1cn(C2CCN(CC2)C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)c(=O)[nH]1 |t:23|
Show InChI InChI=1S/C33H31F3N6O4/c1-46-24-11-7-10-22(18-24)26-19-41(32(45)37-26)23-14-16-40(17-15-23)31(44)39-29-30(43)42(20-33(34,35)36)27-13-6-5-12-25(27)28(38-29)21-8-3-2-4-9-21/h2-13,18-19,23,29H,14-17,20H2,1H3,(H,37,45)(H,39,44)/t29-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 5.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production


Bioorg Med Chem Lett 16: 5052-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.044
BindingDB Entry DOI: 10.7270/Q29S1QNX
More data for this
Ligand-Target Pair