BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Casein kinase II subunit alpha' and Ligand = 'BDBM50156669'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE \| 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CK2alpha in human PLC1 cells using (Arg)3(Glu)3Thr(Glu)3 as substrate after 24 hrs in presence of [32P]gammaGTP				Eur J Med Chem 181: (2019) Article DOI: 10.1016/j.ejmech.2019.111581 BindingDB Entry DOI: 10.7270/Q29K4FJB
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE \| 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Colorado State University Curated by ChEMBL					Assay Description Inhibition of human wild type CK2alpha				J Med Chem 59: 1655-70 (2016) Article DOI: 10.1021/acs.jmedchem.5b00997 BindingDB Entry DOI: 10.7270/Q24T6M70
Colorado State University Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE \| 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	315	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The John Paul II Catholic University of Lublin Curated by ChEMBL					Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s...				Eur J Med Chem 47: 345-50 (2012) Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE \| 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	462	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The John Paul II Catholic University of Lublin Curated by ChEMBL					Assay Description Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ...				Eur J Med Chem 47: 345-50 (2012) Article DOI: 10.1016/j.ejmech.2011.11.002 BindingDB Entry DOI: 10.7270/Q2377944
					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE \| 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Warsaw University of Technology					Assay Description The activity of CK2α was tested using P81 filter isotopic assay, as it was described earlier [Łukowska-Chojnacka et al., Bioorg. Med. Chem....				Bioorg Chem 72: 1-10 (2017) Article DOI: 10.1016/j.bioorg.2017.02.017 BindingDB Entry DOI: 10.7270/Q2J10216
Warsaw University of Technology					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE \| 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Warsaw University of Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate peptide by scintillation counter in presence of [32P]ATP				Bioorg Med Chem 24: 735-41 (2016) Article DOI: 10.1016/j.bmc.2015.12.041 BindingDB Entry DOI: 10.7270/Q2571DV4
Warsaw University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE \| 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Tartu Curated by ChEMBL					Assay Description Displacement of 5-TAMRA-labeled ARC-1530 from CK2alpha (unknown origin) (1 to 335 residues) after 15 to 60 mins by luminescence assay				Bioorg Med Chem 26: 5062-5068 (2018) Article DOI: 10.1016/j.bmc.2018.09.003 BindingDB Entry DOI: 10.7270/Q26112V7
University of Tartu Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase II subunit alpha (Homo sapiens (Human))	BDBM50156669 (4,5,6,7-TETRABROMO-BENZIMIDAZOLE \| 4,5,6,7-tetrabr...) Show SMILES Brc1c(Br)c(Br)c2[nH]cnc2c1Br Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biochemistry and Biophysics Curated by ChEMBL					Assay Description Inhibition of human recombinant casein kinase 2 subunit alpha expressed in Escherichia coli BL21 (DE3) assessed as [32P] incorporation by liquid scin...				Bioorg Med Chem 17: 1573-8 (2009) Article DOI: 10.1016/j.bmc.2008.12.071 BindingDB Entry DOI: 10.7270/Q23J3CVZ
Institute of Biochemistry and Biophysics Curated by ChEMBL					More data for this Ligand-Target Pair