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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Cereblon isoform 4' and Ligand = 'BDBM7814'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cereblon isoform 4


(Magnetospirillum gryphiswaldense)
BDBM7814
PNG
(Maleimide-Related Compound 13 | pyrrolidine-2,5-di...)
Show SMILES O=C1CCC(=O)N1
Show InChI InChI=1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)
PDB

UniProtKB/TrEMBL

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MCE
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
642n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST based assay


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00440
BindingDB Entry DOI: 10.7270/Q2WM1J1B
More data for this
Ligand-Target Pair
Cereblon isoform 4


(Magnetospirillum gryphiswaldense)
BDBM7814
PNG
(Maleimide-Related Compound 13 | pyrrolidine-2,5-di...)
Show SMILES O=C1CCC(=O)N1
Show InChI InChI=1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

MCE
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
4.30E+3n/an/an/an/an/an/an/an/a



Max Planck Institute for Developmental Biology

Curated by ChEMBL


Assay Description
Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysis


J Med Chem 59: 770-4 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01735
BindingDB Entry DOI: 10.7270/Q2PR7XVF
More data for this
Ligand-Target Pair
Cereblon isoform 4


(Magnetospirillum gryphiswaldense)
BDBM7814
PNG
(Maleimide-Related Compound 13 | pyrrolidine-2,5-di...)
Show SMILES O=C1CCC(=O)N1
Show InChI InChI=1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

MCE
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
4.30E+3n/an/an/an/an/an/an/an/a



Max Planck Institute for Developmental Biology

Curated by ChEMBL


Assay Description
Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assay


J Med Chem 62: 6615-6629 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00454
BindingDB Entry DOI: 10.7270/Q2JH3QK6
More data for this
Ligand-Target Pair
Cereblon isoform 4


(Magnetospirillum gryphiswaldense)
BDBM7814
PNG
(Maleimide-Related Compound 13 | pyrrolidine-2,5-di...)
Show SMILES O=C1CCC(=O)N1
Show InChI InChI=1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

MCE
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.53E+3n/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST based assay


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00440
BindingDB Entry DOI: 10.7270/Q2WM1J1B
More data for this
Ligand-Target Pair
Cereblon isoform 4


(Magnetospirillum gryphiswaldense)
BDBM7814
PNG
(Maleimide-Related Compound 13 | pyrrolidine-2,5-di...)
Show SMILES O=C1CCC(=O)N1
Show InChI InChI=1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
Purchase

MCE
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.60E+3n/an/an/an/an/an/a



Max Planck Institute for Developmental Biology

Curated by ChEMBL


Assay Description
Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assay


J Med Chem 59: 770-4 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01735
BindingDB Entry DOI: 10.7270/Q2PR7XVF
More data for this
Ligand-Target Pair