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Found 1 hit Enz. Inhib. hit(s) with Target = 'Chromobox protein homolog 8' and Ligand = 'BDBM50194253'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Chromobox protein homolog 8


(Homo sapiens (Human))		BDBM50194253
PNG
(CHEMBL3946489)
Show SMILES [#6]-[#8]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7]\[#6](-[#7](-[#6])-[#6])=[#7+](/[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-c1ccccc1 |r|
Show InChI InChI=1S/C42H63N9O9/c1-27(2)23-32(40(58)47-31(38(56)49-34(26-52)41(59)60-8)21-15-16-22-43-42(50(4)5)51(6)7)48-36(54)28(3)45-39(57)33(24-29-17-11-9-12-18-29)46-35(53)25-44-37(55)30-19-13-10-14-20-30/h9-14,17-20,27-28,31-34,52H,15-16,21-26H2,1-8H3,(H6,44,45,46,47,48,49,53,54,55,56,57,58)/p+1/t28-,31-,32-,33-,34-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>6.00E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human N-terminal His-tagged CBX8 chromodomain (8 to 61 residues) expressed in Escherichia coli Rosetta BL21(DE3)pL...

J Med Chem 59: 8913-8923 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00801
BindingDB Entry DOI: 10.7270/Q2H1340D
More data for this
Ligand-Target Pair