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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor X' and Ligand = 'BDBM50191349'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))		BDBM50191349
PNG
(CHEMBL3926417)
Show SMILES C[C@H]1COC(=O)Nc2ccc(C(N)=O)c(CN(C)C(=O)[C@H](Nc3ccc4c(N)nccc4c3)c3ccc1c(C)c3)c2 |r|
Show InChI InChI=1S/C31H32N6O4/c1-17-12-20-4-7-24(17)18(2)16-41-31(40)36-23-6-9-26(29(33)38)21(14-23)15-37(3)30(39)27(20)35-22-5-8-25-19(13-22)10-11-34-28(25)32/h4-14,18,27,35H,15-16H2,1-3H3,(H2,32,34)(H2,33,38)(H,36,40)/t18-,27+/m0/s1
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Article
PubMed
>9.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb R&D

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectroph...

J Med Chem 59: 7125-37 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00469
BindingDB Entry DOI: 10.7270/Q2TM7D37
More data for this
Ligand-Target Pair