new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Corticotropin releasing factor receptor 1' and Ligand = 'BDBM50074527'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50074527
PNG
(CHEMBL169641 | [3-(2-Bromo-4-isopropyl-phenyl)-2,5...)
Show SMILES COCCN(CCOC)c1cc(C)nc2n(c(C)nc12)-c1ccc(cc1Br)C(C)C |(13.97,1.76,;13.97,.21,;12.64,-.56,;12.64,-2.11,;11.31,-2.87,;9.98,-2.11,;8.65,-2.87,;7.3,-2.11,;5.97,-2.87,;11.31,-4.41,;9.98,-5.18,;9.98,-6.72,;8.63,-7.5,;11.31,-7.49,;12.64,-6.72,;14.11,-7.19,;15.01,-5.95,;16.55,-5.97,;14.11,-4.71,;12.64,-5.18,;14.74,-8.6,;13.83,-9.84,;14.46,-11.26,;15.99,-11.42,;16.9,-10.17,;16.27,-8.76,;17.18,-7.51,;16.6,-12.84,;15.69,-14.08,;18.14,-13.01,)|
Show InChI InChI=1S/C23H31BrN4O2/c1-15(2)18-7-8-20(19(24)14-18)28-17(4)26-22-21(13-16(3)25-23(22)28)27(9-11-29-5)10-12-30-6/h7-8,13-15H,9-12H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
9.80n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells


J Med Chem 42: 833-48 (1999)


Article DOI: 10.1021/jm980224g
BindingDB Entry DOI: 10.7270/Q2610ZGP
More data for this
Ligand-Target Pair