Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 4' and Ligand = 'BDBM132296'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM132296 (US8841312, 39) Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCCCCC2)c2ccccc32)nc1 Show InChI InChI=1S/C26H31N7/c1-2-4-8-19(7-3-1)33-23-10-6-5-9-21(23)22-18-29-26(31-25(22)33)30-24-12-11-20(17-28-24)32-15-13-27-14-16-32/h5-6,9-12,17-19,27H,1-4,7-8,13-16H2,(H,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
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