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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 6' and Ligand = 'BDBM132283'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM132283
PNG
(US8841312, 26)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(c2cnccc32)C23CC4CC(CC(C4)C2)C3)nc1 |TLB:31:30:33:27.26.25,31:26:33:30.32.29,17:24:27:30.31.29,THB:32:30:27:33.24.25,32:24:27:30.31.29|
Show InChI InChI=1S/C28H32N8/c1-2-25(31-15-21(1)35-7-5-29-6-8-35)33-27-32-16-23-22-3-4-30-17-24(22)36(26(23)34-27)28-12-18-9-19(13-28)11-20(10-18)14-28/h1-4,15-20,29H,5-14H2,(H,31,32,33,34)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair