BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'D(2) dopamine receptor' and Ligand = 'BDBM50020221'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for the inhibition of [3H]-raclopride binding to Dopamine receptor D2 in rat striatum				Bioorg Med Chem Lett 7: 2759-2764 (1997) Article DOI: 10.1016/S0960-894X(97)10068-3 BindingDB Entry DOI: 10.7270/Q2F47P56
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description In vitro binding affinity of the compound is the ability to displace [3H]-N-0437 from human Dopamine receptor D2 expressed in CHO-K1 cells				J Med Chem 38: 3132-7 (1995) BindingDB Entry DOI: 10.7270/Q28W3C9S
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medicinaregatan Curated by ChEMBL					Assay Description Binding affinity against dopamine receptor D2 in rat brain tissue using [3H]spiperone				J Med Chem 36: 3409-16 (1993) BindingDB Entry DOI: 10.7270/Q2X067NP
Medicinaregatan Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description In vitro binding affinity of the compound is the ability to displace [3H]-spiperone from human Dopamine receptor D2 expressed in CHO-K1 cells				J Med Chem 38: 3132-7 (1995) BindingDB Entry DOI: 10.7270/Q28W3C9S
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	58.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from rat dopamine D2L receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3923-33 (2009) Article DOI: 10.1016/j.bmc.2009.04.031 BindingDB Entry DOI: 10.7270/Q25H7G8C
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	58.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine D2L receptor expressed in HEK293 cells				J Med Chem 53: 1023-37 (2010) Article DOI: 10.1021/jm901184n BindingDB Entry DOI: 10.7270/Q29023VM
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	58.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from rat D2 receptor expressed in HEK293 cells				Bioorg Med Chem 18: 5661-74 (2010) Article DOI: 10.1016/j.bmc.2010.06.025 BindingDB Entry DOI: 10.7270/Q2W37WJ9
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	153	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from rat D2L dopamine receptor expressed in HEK293 cell membranes after 1 hr				Bioorg Med Chem 24: 5088-5102 (2016) Article DOI: 10.1016/j.bmc.2016.08.021 BindingDB Entry DOI: 10.7270/Q2B85CNF
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
State University of Groningen Curated by ChEMBL					Assay Description Potency to displace the specific in vitro binding of [3H]DP-5,6-ADTN to rat striatal membrane				J Med Chem 31: 2178-82 (1988) BindingDB Entry DOI: 10.7270/Q22R3S82
State University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10.4	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding				Bioorg Med Chem 17: 3923-33 (2009) Article DOI: 10.1016/j.bmc.2009.04.031 BindingDB Entry DOI: 10.7270/Q25H7G8C
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50020221 ((-)-5-hydroxy-2-(dipropylamino)tetralin \| (-)-6-(d...) Show SMILES CCCN(CCC)C1CCc2c(O)cccc2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	41.2	n/a	n/a	n/a	n/a
Wayne State University Curated by ChEMBL					Assay Description Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding				J Med Chem 53: 1023-37 (2010) Article DOI: 10.1021/jm901184n BindingDB Entry DOI: 10.7270/Q29023VM
Wayne State University Curated by ChEMBL					More data for this Ligand-Target Pair