Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter | J Med Chem 59: 2973-88 (2016) Article DOI: 10.1021/acs.jmedchem.5b01612 BindingDB Entry DOI: 10.7270/Q2708393 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 146 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Displacement of [3H]N-methylspiperone from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter | J Med Chem 59: 2973-88 (2016) Article DOI: 10.1021/acs.jmedchem.5b01612 BindingDB Entry DOI: 10.7270/Q2708393 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused GalphaoA/GFP10-fused Ggamma2 assess... | J Med Chem 60: 2890-2907 (2017) Article DOI: 10.1021/acs.jmedchem.6b01875 BindingDB Entry DOI: 10.7270/Q28P62SD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Binding affinity for Progesterone receptor (PR) in human T47D breast carcinoma cells | J Med Chem 60: 2890-2907 (2017) Article DOI: 10.1021/acs.jmedchem.6b01875 BindingDB Entry DOI: 10.7270/Q28P62SD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 931 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Antagonist activity at human dopamine D2 receptor expressed in forskolin stimulated-HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10... | J Med Chem 60: 2890-2907 (2017) Article DOI: 10.1021/acs.jmedchem.6b01875 BindingDB Entry DOI: 10.7270/Q28P62SD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET a... | J Med Chem 60: 2890-2907 (2017) Article DOI: 10.1021/acs.jmedchem.6b01875 BindingDB Entry DOI: 10.7270/Q28P62SD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line | J Med Chem 60: 2890-2907 (2017) Article DOI: 10.1021/acs.jmedchem.6b01875 BindingDB Entry DOI: 10.7270/Q28P62SD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Inhibitory constant against trypsin determined in Vitro | J Med Chem 60: 2890-2907 (2017) Article DOI: 10.1021/acs.jmedchem.6b01875 BindingDB Entry DOI: 10.7270/Q28P62SD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t... | J Med Chem 59: 2973-88 (2016) Article DOI: 10.1021/acs.jmedchem.5b01612 BindingDB Entry DOI: 10.7270/Q2708393 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 34 | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assay | J Med Chem 59: 2973-88 (2016) Article DOI: 10.1021/acs.jmedchem.5b01612 BindingDB Entry DOI: 10.7270/Q2708393 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50164855 (CHEMBL3797209) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL | Assay Description Inhibitory constant against trypsin determined in Vitro | J Med Chem 60: 2890-2907 (2017) Article DOI: 10.1021/acs.jmedchem.6b01875 BindingDB Entry DOI: 10.7270/Q28P62SD | |||||||||||
More data for this Ligand-Target Pair |