BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'D(2) dopamine receptor' and Ligand = 'BDBM50241119'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NeuroSearch Sweden AB Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells				J Med Chem 53: 2510-20 (2010) Article DOI: 10.1021/jm901689v BindingDB Entry DOI: 10.7270/Q2NG4RKK
NeuroSearch Sweden AB Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NeuroSearch Sweden AB Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine D2 receptor at low affinity state expressed in HEK293 cells				J Med Chem 53: 2510-20 (2010) Article DOI: 10.1021/jm901689v BindingDB Entry DOI: 10.7270/Q2NG4RKK
NeuroSearch Sweden AB Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [3H]raclopride from human D2 dopamine receptor expressed in CHO cell membranes				Bioorg Med Chem Lett 23: 543-7 (2012) Article DOI: 10.1016/j.bmcl.2012.11.023 BindingDB Entry DOI: 10.7270/Q2639R2X
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pierre Fabre Research Center Curated by ChEMBL					Assay Description Displacement of [3H]YM-09151-2 from rat striatum D2 receptor				J Med Chem 50: 865-76 (2007) Article DOI: 10.1021/jm061180b BindingDB Entry DOI: 10.7270/Q2ZS309D
Pierre Fabre Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio Grande do Sul Curated by ChEMBL					Assay Description Agonist activity at dopamine D2 receptor				Bioorg Med Chem 18: 1925-35 (2010) Article DOI: 10.1016/j.bmc.2010.01.040 BindingDB Entry DOI: 10.7270/Q2S75H99
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Solvay Pharma Curated by ChEMBL					Assay Description Binding affinity for dopamine receptor D2 determined using [3H]-spiperone				Bioorg Med Chem Lett 11: 2345-9 (2001) BindingDB Entry DOI: 10.7270/Q2RR1XH9
Solvay Pharma Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]nemonapride from dopamine D2L receptor (unknown origin) expressed in African green monkey COS7 cells				J Med Chem 57: 5823-8 (2014) Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	8.81	-46.0	n/a	n/a	n/a	n/a	n/a	7.4	25
King Fahd University of Petroleum & Minerals					Assay Description Human-cloned dopamine D2L receptors stably expressed in C6 rat glioma cells (kindly donated by Professor Roberto Maggio, Università di L'Aquil...				J Enzyme Inhib Med Chem 29: 281-91 (2014) Article DOI: 10.3109/14756366.2013.776556 BindingDB Entry DOI: 10.7270/Q2SN07WV
King Fahd University of Petroleum & Minerals					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50241119 (7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human D2 dopamine receptor expressed in CHO cell membrane by GTPgammaS-binding assay				Bioorg Med Chem Lett 23: 543-7 (2012) Article DOI: 10.1016/j.bmcl.2012.11.023 BindingDB Entry DOI: 10.7270/Q2639R2X
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair