Found 2 hits Enz. Inhib. hit(s) with Target = 'D(2) dopamine receptor' and Ligand = 'BDBM50395586' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50395586
(CHEMBL2165128)Show SMILES Clc1cccc(N2CCN(C[C@H]3CC[C@H](COc4ccc5CCC(=O)Nc5c4)CC3)CC2)c1Cl |r,wU:11.10,wD:14.14,(.73,-4.74,;.75,-6.28,;-.59,-7.06,;-.55,-8.61,;.79,-9.36,;2.11,-8.57,;3.45,-9.32,;3.47,-10.85,;4.81,-11.61,;6.13,-10.82,;7.46,-11.58,;8.79,-10.79,;8.77,-9.25,;10.1,-8.47,;11.45,-9.22,;12.77,-8.44,;12.76,-6.9,;14.07,-6.1,;15.42,-6.85,;16.74,-6.05,;16.7,-4.52,;18.03,-3.72,;18,-2.18,;16.64,-1.42,;16.6,.12,;15.3,-2.23,;15.34,-3.77,;14.03,-4.57,;11.46,-10.76,;10.14,-11.54,;6.12,-9.28,;4.78,-8.54,;2.09,-7.03,;3.42,-6.24,)| Show InChI InChI=1S/C27H33Cl2N3O2/c28-23-2-1-3-25(27(23)29)32-14-12-31(13-15-32)17-19-4-6-20(7-5-19)18-34-22-10-8-21-9-11-26(33)30-24(21)16-22/h1-3,8,10,16,19-20H,4-7,9,11-15,17-18H2,(H,30,33)/t19-,20- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 145 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description Displacement of [3H]N-methylspiperone from human D2L receptor expressed in CHO cells after 1.5 hrs by microbeta counting method |
J Med Chem 55: 7141-53 (2012)
Article DOI: 10.1021/jm300603y BindingDB Entry DOI: 10.7270/Q2JD4XXH |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50395586
(CHEMBL2165128)Show SMILES Clc1cccc(N2CCN(C[C@H]3CC[C@H](COc4ccc5CCC(=O)Nc5c4)CC3)CC2)c1Cl |r,wU:11.10,wD:14.14,(.73,-4.74,;.75,-6.28,;-.59,-7.06,;-.55,-8.61,;.79,-9.36,;2.11,-8.57,;3.45,-9.32,;3.47,-10.85,;4.81,-11.61,;6.13,-10.82,;7.46,-11.58,;8.79,-10.79,;8.77,-9.25,;10.1,-8.47,;11.45,-9.22,;12.77,-8.44,;12.76,-6.9,;14.07,-6.1,;15.42,-6.85,;16.74,-6.05,;16.7,-4.52,;18.03,-3.72,;18,-2.18,;16.64,-1.42,;16.6,.12,;15.3,-2.23,;15.34,-3.77,;14.03,-4.57,;11.46,-10.76,;10.14,-11.54,;6.12,-9.28,;4.78,-8.54,;2.09,-7.03,;3.42,-6.24,)| Show InChI InChI=1S/C27H33Cl2N3O2/c28-23-2-1-3-25(27(23)29)32-14-12-31(13-15-32)17-19-4-6-20(7-5-19)18-34-22-10-8-21-9-11-26(33)30-24(21)16-22/h1-3,8,10,16,19-20H,4-7,9,11-15,17-18H2,(H,30,33)/t19-,20- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.58E+3 | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill
Curated by ChEMBL
| Assay Description Partial agonist activity at D2L receptor in human HTLA cells assessed as beta arrestin recruitment at 6 uM after 18 hrs by luminescence assay |
J Med Chem 55: 7141-53 (2012)
Article DOI: 10.1021/jm300603y BindingDB Entry DOI: 10.7270/Q2JD4XXH |
More data for this Ligand-Target Pair | |