Found 9 hits Enz. Inhib. hit(s) with Target = 'D(2) dopamine receptor' and Ligand = 'BDBM81195' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.07 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDA Addiction Research Center
Curated by PDSP Ki Database
| |
Life Sci 45: 1821-9 (1989)
Article DOI: 10.1016/0024-3205(89)90523-7 BindingDB Entry DOI: 10.7270/Q20Z71SN |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 262: 929-35 (1992)
BindingDB Entry DOI: 10.7270/Q2RR1WQK |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 262: 929-35 (1992)
BindingDB Entry DOI: 10.7270/Q2RR1WQK |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 24.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDA Addiction Research Center
Curated by PDSP Ki Database
| |
Life Sci 45: 1821-9 (1989)
Article DOI: 10.1016/0024-3205(89)90523-7 BindingDB Entry DOI: 10.7270/Q20Z71SN |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania
Curated by ChEMBL
| Assay Description Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligand |
J Med Chem 33: 171-8 (1990)
BindingDB Entry DOI: 10.7270/Q2280860 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(BOVINE) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
UniProtKB/SwissProt
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| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 800-12 (1976)
BindingDB Entry DOI: 10.7270/Q22B8WH6 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Catholique de Louvain
Curated by PDSP Ki Database
| |
Life Sci 37: 1971-83 (1985)
Article DOI: 10.1016/0024-3205(85)90028-1 BindingDB Entry DOI: 10.7270/Q2HX1B5B |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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| n/a | n/a | 0 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist required to inhibit Dopamine receptor D2 photoinactivation by 50% with Iodazidoclebopride using [3H]-Spiperone |
J Med Chem 28: 405-7 (1985)
BindingDB Entry DOI: 10.7270/Q2542P5T |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM81195
((+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaph...)Show InChI InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Crete
Curated by ChEMBL
| Assay Description Inhibition of specific binding of [3H]spiroperidol to Dopamine receptor D2 in rat striatal membranes |
J Med Chem 41: 4165-70 (1998)
Article DOI: 10.1021/jm980284m BindingDB Entry DOI: 10.7270/Q2N87BFW |
More data for this Ligand-Target Pair | |