BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with Target = 'D(2) dopamine receptor' and Ligand = 'BDBM84636'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Compound was evaluated for its ability to inhibit Dopamine receptor D2 in rat striatum using [3H]spiperone				J Med Chem 34: 24-8 (1991) BindingDB Entry DOI: 10.7270/Q24Q7VKQ
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Binding affinity against Dopamine receptor D2 from rat brain corpus striatal preparations using [3H]-Spiperone				J Med Chem 31: 1392-6 (1988) BindingDB Entry DOI: 10.7270/Q2WW7GP2
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Displacement of [3H]domperidone from dopamine D2 receptor high binding site in Sprague-Dawley rat striatum by scintillation counting				ACS Med Chem Lett 2: 189-194 (2011) Article DOI: 10.1021/ml1001689 BindingDB Entry DOI: 10.7270/Q2Z89DF8
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Displacement of [3H]-raclopride from human Dopamine receptor D2A				J Med Chem 39: 3503-13 (1996) Article DOI: 10.1021/jm960189i BindingDB Entry DOI: 10.7270/Q2T43S6S
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	28.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Displacement of [3H]neomonapride from dopamine D2 receptor in rat corpus striatum				Bioorg Med Chem Lett 18: 3971-3 (2008) Article DOI: 10.1016/j.bmcl.2008.06.016 BindingDB Entry DOI: 10.7270/Q2S46RRC
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	28.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Displacement of [3H]nemonapride from dopamine D2 receptor in rat forebrain				Bioorg Med Chem Lett 19: 51-3 (2008) Article DOI: 10.1016/j.bmcl.2008.11.025 BindingDB Entry DOI: 10.7270/Q26W99XP
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of [3H]raclopride from rat dopamine D2 receptor				J Med Chem 50: 171-81 (2007) Article DOI: 10.1021/jm060959i BindingDB Entry DOI: 10.7270/Q22J6CPJ
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	114	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from dopamine D2 receptor expressed in HEK293 cells by liquid scintillation counting				J Med Chem 53: 1319-28 (2010) Article DOI: 10.1021/jm9015763 BindingDB Entry DOI: 10.7270/Q2T154KK
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	789	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Toronto Curated by PDSP K_i Database									Eur J Pharmacol 233: 173-4 (1993) Article DOI: 10.1016/0014-2999(93)90365-o BindingDB Entry DOI: 10.7270/Q25D8QBH
University of Toronto Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.41E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Displacement of [3H]SCH23390 from dopamine D2 receptor low binding site in Sprague-Dawley rat striatum by scintillation counting				ACS Med Chem Lett 2: 189-194 (2011) Article DOI: 10.1021/ml1001689 BindingDB Entry DOI: 10.7270/Q2Z89DF8
Harvard Medical School Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM84636 (CHEMBL27559 \| NPA-11-OH-R,(+)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from human dopamine D2 receptor expressed in HEK293 cells				Bioorg Med Chem 16: 8335-8 (2008) Article DOI: 10.1016/j.bmc.2008.08.056 BindingDB Entry DOI: 10.7270/Q2Q52PG5
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair