Compile Data Set for Download or QSAR

Found 7 hits Enz. Inhib. hit(s) with Target = 'D(4) dopamine receptor' and Ligand = 'BDBM50145075'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50145075 (2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benz...) Show SMILES C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	167	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity against human Dopamine receptor D4 by [3H]-spiperone displacement.				J Med Chem 47: 2348-55 (2004) Article DOI: 10.1021/jm0305669 BindingDB Entry DOI: 10.7270/Q2M61M03
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM50145075 (2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benz...) Show SMILES C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat D4 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR				J Med Chem 49: 7450-65 (2006) Article DOI: 10.1021/jm060662k BindingDB Entry DOI: 10.7270/Q25X28MM
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM50145075 (2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benz...) Show SMILES C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	14.3	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D4 using FLIPR assay				J Med Chem 47: 3853-64 (2004) Article DOI: 10.1021/jm030505a BindingDB Entry DOI: 10.7270/Q24B3225
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM50145075 (2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benz...) Show SMILES C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	23.2	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay				J Med Chem 47: 3853-64 (2004) Article DOI: 10.1021/jm030505a BindingDB Entry DOI: 10.7270/Q24B3225
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50145075 (2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benz...) Show SMILES C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	12.4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro EC50 tested on HEK293 cells co-transfected with human Dopamine receptor D4.4 using FLIPR assay				J Med Chem 47: 3853-64 (2004) Article DOI: 10.1021/jm030505a BindingDB Entry DOI: 10.7270/Q24B3225
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50145075 (2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benz...) Show SMILES C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at human D4.4 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR				J Med Chem 49: 7450-65 (2006) Article DOI: 10.1021/jm060662k BindingDB Entry DOI: 10.7270/Q25X28MM
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50145075 (2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benz...) Show SMILES C(N1CCN(CC1)c1ccccn1)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	12.4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description D4 efficacy was measured using recombinant human Dopamine receptor D4 expressed in HEK293 cells				J Med Chem 47: 2348-55 (2004) Article DOI: 10.1021/jm0305669 BindingDB Entry DOI: 10.7270/Q2M61M03
					More data for this Ligand-Target Pair