Found 11 hits Enz. Inhib. hit(s) with Target = 'D-amino-acid oxidase' and Ligand = 'BDBM31147' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by Lineweaver-Burk plot... |
J Med Chem 56: 1894-907 (2013)
Article DOI: 10.1021/jm3017865 BindingDB Entry DOI: 10.7270/Q2H70H4P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | 8.5 | 22 |
Pfizer
| Assay Description Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox... |
J Med Chem 52: 3576-85 (2009)
Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | 17.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescenc... |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme
Curated by ChEMBL
| Assay Description Inhibition of human DAO |
Bioorg Med Chem Lett 18: 3386-91 (2008)
Article DOI: 10.1016/j.bmcl.2008.04.020 BindingDB Entry DOI: 10.7270/Q2WQ03KS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay |
J Med Chem 56: 1894-907 (2013)
Article DOI: 10.1021/jm3017865 BindingDB Entry DOI: 10.7270/Q2H70H4P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | 214 | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by colorimetric assay |
J Med Chem 56: 1894-907 (2013)
Article DOI: 10.1021/jm3017865 BindingDB Entry DOI: 10.7270/Q2H70H4P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Rattus norvegicus (rat)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 424 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox... |
J Med Chem 52: 3576-85 (2009)
Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM |
More data for this Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO by steady state study scintillation proximity assay |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assay |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description Binding affinity and kinetics were measured using biotinylated recombinant human DAAO bound to a Neutravidin surface in a Biacore binding assay. A cu... |
J Med Chem 52: 3576-85 (2009)
Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM31147
(4H-furo[3,2-b]pyrrole-5-carboxylic acid | 5-carbox...)Show InChI InChI=1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
| MMDB PDB Article PubMed
| n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a |
Abbott Healthcare Products B.V.
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysis |
Eur J Med Chem 46: 4808-19 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.023 BindingDB Entry DOI: 10.7270/Q2BK1CRC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |