Found 3 hits Enz. Inhib. hit(s) with Target = 'Deoxyribonuclease gamma' and Ligand = 'BDBM50206432' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Deoxyribonuclease gamma
(Homo sapiens (Human)) | BDBM50206432
(4-(4,6-dichloro-1,3,5-triazin-2-ylamino)-2-(6-hydr...)Show SMILES OC(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1-c1c2ccc(O)cc2oc2cc(=O)ccc12 |(23.23,-31.33,;23.79,-29.89,;22.82,-28.7,;25.31,-29.65,;25.3,-28.12,;26.63,-27.33,;27.97,-28.1,;29.3,-27.32,;29.29,-25.78,;27.95,-25.03,;27.94,-23.49,;26.6,-22.73,;29.28,-22.71,;30.61,-23.47,;31.94,-22.69,;30.62,-25.01,;27.98,-29.63,;26.64,-30.4,;26.65,-31.94,;27.99,-32.7,;29.32,-31.92,;30.66,-32.68,;30.67,-34.23,;32.01,-34.99,;29.34,-35.01,;28,-34.25,;26.66,-35.02,;25.33,-34.26,;23.99,-35.04,;22.66,-34.27,;21.33,-35.03,;22.66,-32.72,;23.99,-31.95,;25.33,-32.71,)| Show InChI InChI=1S/C23H12Cl2N4O5/c24-21-27-22(25)29-23(28-21)26-10-1-4-13(20(32)33)16(7-10)19-14-5-2-11(30)8-17(14)34-18-9-12(31)3-6-15(18)19/h1-9,30H,(H,32,33)(H,26,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nis
Curated by ChEMBL
| Assay Description Inhibition of DNase gamma (unknown origin) transfected in HeLa S3 cells |
Eur J Med Chem 88: 101-11 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.040 BindingDB Entry DOI: 10.7270/Q2M32XC3 |
More data for this Ligand-Target Pair | |
Deoxyribonuclease gamma
(Homo sapiens (Human)) | BDBM50206432
(4-(4,6-dichloro-1,3,5-triazin-2-ylamino)-2-(6-hydr...)Show SMILES OC(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1-c1c2ccc(O)cc2oc2cc(=O)ccc12 |(23.23,-31.33,;23.79,-29.89,;22.82,-28.7,;25.31,-29.65,;25.3,-28.12,;26.63,-27.33,;27.97,-28.1,;29.3,-27.32,;29.29,-25.78,;27.95,-25.03,;27.94,-23.49,;26.6,-22.73,;29.28,-22.71,;30.61,-23.47,;31.94,-22.69,;30.62,-25.01,;27.98,-29.63,;26.64,-30.4,;26.65,-31.94,;27.99,-32.7,;29.32,-31.92,;30.66,-32.68,;30.67,-34.23,;32.01,-34.99,;29.34,-35.01,;28,-34.25,;26.66,-35.02,;25.33,-34.26,;23.99,-35.04,;22.66,-34.27,;21.33,-35.03,;22.66,-32.72,;23.99,-31.95,;25.33,-32.71,)| Show InChI InChI=1S/C23H12Cl2N4O5/c24-21-27-22(25)29-23(28-21)26-10-1-4-13(20(32)33)16(7-10)19-14-5-2-11(30)8-17(14)34-18-9-12(31)3-6-15(18)19/h1-9,30H,(H,32,33)(H,26,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DNase gamma expressed in Rosetta DE3 cells assessed as increase in acidsoluble DNA after 30 mins |
Bioorg Med Chem 19: 168-71 (2011)
Article DOI: 10.1016/j.bmc.2010.11.037 BindingDB Entry DOI: 10.7270/Q2PK0GDV |
More data for this Ligand-Target Pair | |
Deoxyribonuclease gamma
(Homo sapiens (Human)) | BDBM50206432
(4-(4,6-dichloro-1,3,5-triazin-2-ylamino)-2-(6-hydr...)Show SMILES OC(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1-c1c2ccc(O)cc2oc2cc(=O)ccc12 |(23.23,-31.33,;23.79,-29.89,;22.82,-28.7,;25.31,-29.65,;25.3,-28.12,;26.63,-27.33,;27.97,-28.1,;29.3,-27.32,;29.29,-25.78,;27.95,-25.03,;27.94,-23.49,;26.6,-22.73,;29.28,-22.71,;30.61,-23.47,;31.94,-22.69,;30.62,-25.01,;27.98,-29.63,;26.64,-30.4,;26.65,-31.94,;27.99,-32.7,;29.32,-31.92,;30.66,-32.68,;30.67,-34.23,;32.01,-34.99,;29.34,-35.01,;28,-34.25,;26.66,-35.02,;25.33,-34.26,;23.99,-35.04,;22.66,-34.27,;21.33,-35.03,;22.66,-32.72,;23.99,-31.95,;25.33,-32.71,)| Show InChI InChI=1S/C23H12Cl2N4O5/c24-21-27-22(25)29-23(28-21)26-10-1-4-13(20(32)33)16(7-10)19-14-5-2-11(30)8-17(14)34-18-9-12(31)3-6-15(18)19/h1-9,30H,(H,32,33)(H,26,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science
Curated by ChEMBL
| Assay Description Inhibition of DNase gamma-mediated HMGB1 release expressed in human staurosporine-induced HeLaS3 cells treated 1 hr before staurosporine challenge me... |
Bioorg Med Chem 19: 168-71 (2011)
Article DOI: 10.1016/j.bmc.2010.11.037 BindingDB Entry DOI: 10.7270/Q2PK0GDV |
More data for this Ligand-Target Pair | |