Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50020050' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020050
(CHEMBL3287875)Show SMILES CCc1ccccc1NC(=O)N1CCOc2cc(ccc12)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:30.34,wD:27.30,(.52,-9.03,;2.06,-9.03,;2.83,-7.69,;2.06,-6.36,;2.83,-5.03,;4.37,-5.03,;5.14,-6.36,;4.37,-7.69,;5.14,-9.03,;6.68,-9.03,;7.45,-7.69,;7.45,-10.36,;6.68,-11.7,;7.45,-13.03,;8.99,-13.03,;9.76,-11.7,;11.3,-11.7,;12.07,-10.36,;11.3,-9.03,;9.76,-9.03,;8.99,-10.36,;13.61,-10.36,;14.38,-11.7,;15.92,-11.7,;16.69,-10.36,;15.92,-9.03,;14.38,-9.03,;18.23,-10.36,;19,-11.7,;20.54,-11.7,;21.31,-10.36,;22.85,-10.36,;23.62,-11.7,;25.16,-11.7,;22.85,-13.03,;20.54,-9.03,;19,-9.03,)| Show InChI InChI=1S/C31H34N2O4/c1-2-22-5-3-4-6-27(22)32-31(36)33-17-18-37-29-20-26(15-16-28(29)33)25-13-11-24(12-14-25)23-9-7-21(8-10-23)19-30(34)35/h3-6,11-16,20-21,23H,2,7-10,17-19H2,1H3,(H,32,36)(H,34,35)/t21-,23- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020050
(CHEMBL3287875)Show SMILES CCc1ccccc1NC(=O)N1CCOc2cc(ccc12)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:30.34,wD:27.30,(.52,-9.03,;2.06,-9.03,;2.83,-7.69,;2.06,-6.36,;2.83,-5.03,;4.37,-5.03,;5.14,-6.36,;4.37,-7.69,;5.14,-9.03,;6.68,-9.03,;7.45,-7.69,;7.45,-10.36,;6.68,-11.7,;7.45,-13.03,;8.99,-13.03,;9.76,-11.7,;11.3,-11.7,;12.07,-10.36,;11.3,-9.03,;9.76,-9.03,;8.99,-10.36,;13.61,-10.36,;14.38,-11.7,;15.92,-11.7,;16.69,-10.36,;15.92,-9.03,;14.38,-9.03,;18.23,-10.36,;19,-11.7,;20.54,-11.7,;21.31,-10.36,;22.85,-10.36,;23.62,-11.7,;25.16,-11.7,;22.85,-13.03,;20.54,-9.03,;19,-9.03,)| Show InChI InChI=1S/C31H34N2O4/c1-2-22-5-3-4-6-27(22)32-31(36)33-17-18-37-29-20-26(15-16-28(29)33)25-13-11-24(12-14-25)23-9-7-21(8-10-23)19-30(34)35/h3-6,11-16,20-21,23H,2,7-10,17-19H2,1H3,(H,32,36)(H,34,35)/t21-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
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